The human genome encodes about 25% of the total proteome of
membrane proteins. These membrane proteins are associated with a
variety of diseases such as cystic fibrosis, atherosclerosis,
Parkinson's disease, and Alzheimer's disease. Thus, membrane
proteins are important targets for numerous drug discovery and
clinical therapeutic studies. Ion channels, transporter proteins,
GPCRs, and kinases are the largest class of drug targets in drug
discovery and development, and approximately 40% of approved
antibody drugs exert their pharmacological effects by targeting
GPCR complexes.
Membrane proteins limit their research progress due to low
expression and difficulty in purification.
Creative Biomart has established a comprehensive
membrane protein platform that provides enrichment and
purification of membrane proteins, including Virus-like particles
(VLPs) technology platform, detergent technology platform, Nanodisc
technology platform, and liposome technology platform.
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